Progress in underpinning causes of Chronic Asthma

In an article on, Monique Brouillette explores a groundbreaking discovery shedding light on the mechanical underpinnings of chronic asthma. Researchers have uncovered a glitch in the turnover process of epithelial lung cells, known as cell extrusion, which appears to play a significant role in triggering asthma attacks.

This revelation challenges traditional theories centered around muscle constriction or inflammation, highlighting the crucial influence of mechanical forces in asthma pathology. Led by cell biologist Jody Rosenblatt and her team at King’s College London, the study employed experiments on both mouse lung cells and human airway samples from individuals with asthma. The results revealed pronounced epithelial damage and extrusion, even after treatment with commonly used asthma medications. 


Furthermore, targeting specific cell receptors involved in sensing mechanical pressure showed promise in mitigating lung damage in mice, suggesting a potential avenue for future therapeutic interventions. These findings mark a significant shift in our understanding of asthma, emphasizing the importance of mechanical processes in driving the disease’s progression. By unraveling the role of cell extrusion in asthma pathology, researchers may pave the way for more effective treatment strategies targeting the underlying mechanisms. 


However, further research is needed to validate these findings and explore their potential clinical applications in human subjects. In essence, this study represents a crucial step forward in the quest to unravel the complexities of chronic asthma and develop novel therapeutic approaches aimed at addressing its underlying causes.